ea0026p309 | Obesity | ECE2011
Kobayashi Y
, Daisuke K
, Yamaguchi Y
, Ueda M
, Miyata O
, Tagawa N
Excess glucocorticoids (GC) promote visceral obesity, hyperlipidemia and insulin resistance. The main regulators of intracellular GC levels are 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which converts inactive GC into bioactive forms such as cortisol in humans and corticosterone in rodents. Therefore, the inhibition of 11β-HSD1 has considerable therapeutic potential for metabolic diseases including obesity and diabetes. Benzofran is a key structure in ...